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Blood pressure secret unlocked. Hope for better drug treatment after major breakthrough by British experts.
A breakthrough by British Scientists could pave the way for more effective blood pressure drugs. Experts have discovered how the body regulates blood pressure -- giving them a way to replicate it with medication. They found the condition is naturally reduced when when nerves which surround the arteries release nitric oxide. Scientists last night said the discovery marks a 'fundamental change' in the way they view blood pressure . Previously, experts thought it was regulated by the blood vessel walls themselves, rather that the bundle of nerves surrounding them. The breakthrough also offers a clue about the role stress and emotion play in the condition, because these nerves have a direct link to the brain. High blood pressure -- known as hypertension -- affects one in three adults, more than 17 million of the British population. The condition vastly increases the risk of heart attacks, strokes and vascular dementia, but because it has no symptoms until it is too late, only half of those with the condition know they are at risk. Of those who have bee diagnosed, hundreds of thousands take daily pills to control their blood pressure. However the current treatment is only effective for about half of patients. The discovery, by scientists at King's college London, could allow doctors to mimic the body's method of regulating blood pressure, such as by stimulating the nerves with enzymes so they produce more of the chemical. The research team, whose work is published in the journal Hypertension, made the discovery through experiments on healthy men with normal blood pressure, in which they used a drug to stop the nerves producing nitric acid and found blood pressure rocketed as a result. Professor Ajay Shah, head Cardiologist at Kings college hospital, said: 'Our discovery will fundamentally change the way we view the regulation of blood pressure. 'Until now the majority of blood pressure drugs have focussed on other pathways. 'Establishing that nerves releasing nitric oxide influence blood pressure provides a new target for drugs and could eventually lead to more effective treatment for patients.' Professor Jeremy Pearson, associate medical director at the British Heart Foundation, which part - funded the research said: 'Whilst there are already many treatments for high blood pressure, they are not always effective.' He added: 'These results provide hope of new treatments for people with poorly controlled high blood pressure, which could prove crucial in preventing a heart attack or stroke.'
firstname.lastname@example.org Ben Spencer
How dizzy spells could be early warning signal for dementia'
Dizzy spells in middle age may be a sign of dementia 20 years before symptoms appear, research suggests. People who feel light-headed when they stand up may be more likely to develop the disease than those who don't, it was found. The head rush is due to a drop in blood pressure, which may cause damage to the brain that raises the risk of dementia. In the study of 11,500 people aged between 45 and 64, those with this condition known a s orthostatic hypotension, were 40 per cent more likely to develop dementia. Study leader Dr. Andreea Rawlings, from the Johns Hopkins Bloomberg School of public health in the US, said: 'even though these episodes are fleeting, they may have impacts that are long lasting. It's a significant finding and we need to better understand just what is happening.' The team who presented the study at the American Heart Association's lifestyle Scientific Sessions in Oregon, performed blood pressure tests to find out which participants had orthostatic hypotension. About 6 per cent tested positive and were then tracked over the next 20 years. They were found to be 40 per cent more likely to develop dementia than those who tested negative. Tests showed they had a 15 per cent higher rate of cognitive decline. The researchers said it was not possible to say for certain whether the blood pressure drop was directly linked to Dementia. Dr. Rawlings said more research was needed but the findings could lead to possible strategies for prevention and intervention. Dr. James Pickard, head of research at the Alzheimer's Society, said; 'It is not necessarily a cause for concern but people who frequently experience these symptoms should seek advice from their G.P.
Heart attack fears over use of common painkillers. 'stark reminder' Experts have issued a painkiller warning.'
Common painkillers taken by millions of Britons can raise the risk of a heart attack by up to 50%, researchers have found. And one, diclofenac, is so dangerous it should not be taken at all. Others such as ibrofen, which is sold over the counter in the UK, are not harmless and should be used with caution. Scientists say the pills should not be sold in supermarkets and petrol stations, because there is no professional advice on how to use them. A study of 29,000 patients found any NSAID Nonsterodial anti-inflammatory drug) increased the risk of cardiac arrest by almost a third (31 per cent). Diciofenec and ibrufen -- taken for back pain, headaches, period pains, and other ailments -- were associated with a 50% and a 31 per cent increased risk respectively. The findings follow research last year which showed patients who regularly take the painkillers are up to 20 per cent more likely to develop heart failure. It is believed long-term use of the medications cause chemical reactions in the body which place extra strain on the heart. Professor Gunnar Gislason, of Copenhagen University Hospital in Denmark, said NSAIDs were among the most commonly used drugs worldwide. He added allowing these drugs to be purchased without a prescription, and without any advice sends a message to the public that they are safe. Previous studies have shown that NSAIDs are related to increased cardiovascular risk which is a concern because they are widely used. The study, published in the European Heart Journal, Cardivascular Pharmacotherapy analysed 28,947 patients who had a heart attack outside hospital between 2001 and 2010. Of these, 3,376 were treated with an NSAID up to 30 days before the event. ibuprofen and diclofenac were most commonly used, making up 51 per cent and 22 per cent and 22 per cercent of the total respectively. Prof Gislason said: 'The findings are a stark reminder that NSAIDs are not harmless. Diclofenac and Ibuprofen, both commonly used drugs, were associated with significantly increased risk of cardiac arrest. NSAIDs should be used with caution and for a valid indication. They should probably be avoided in patient with cardiovascular disease or many cardiovascular risk factors. 'I don't think these drugs should be sold in supermarkets or petrol stations where there is no professional advice on how to use them. Over-the-counter NSAIDs should only be available at pharmacies, in limited quantities, and in low doses' He advised patients to take no more than 1,200 mg of ibuprofen a day -- about six small tablets -- and added: 'Diclofenac is the riskiest NSAID and should be avoided by patients with cardiovascular disease and the general population. 'Safer drugs are available that have similar painkiller effects' Diclofenac is no longer sold over the counter in the UK because of concerns about it's effect on the heart. It is available only on prescription. Prof Gislason said: 'Our study adds to the evidence abut the adverse cardiovascular effects of NSAIDs and confirms that THEY SHOULD BE TAKEN SERIOUSLY, and used only after consulting a healthcare professional.' The British Heart foundation says patients should be on the lowest dose possible of NSAIDs for the shortest possible time.
Take 30 minutes to test blood pressure. Michael Blackley March 2017 Daily Mail
Taking patients blood pressure continuously over 30 minutes could significantly reduce the number being misdiagnosed with high blood pressure, say doctors at Gezondheidspectrum Healthcare Centre in Rotterdam. These 30 minte readings could significantly reduce 'white--coat' hypertension --- where blood pressure rises abnormally due to anxiety. In a trial of the technique involving 200 patients, average blood pressure readings fell by 23 mm Hg. This reduced the number told that they needed treatment or increased medication for hypertension.
the pills I take. May effect 1 in 10 People
Losartan Potassium 100 mg film coated Tablets.
Possible side effects.
2) Low blood pressure
3) Dose related orthostatic effects such as lowering blood pressure appearing when rising rising or sitting position)
6) Too little sugar in the blood.
7) Changes in kidney function.
8) Reduced number of red blood cells (anaenia)
9) Increase IN BLOOD Urea, serum creatinine and serum potassium in patients with heart failure.
Solpadol 30 mg/500mg Caplets
Possible side effects.
2) Feeling sick (Nausia), being sick (vomiting)
4) Difficulty in passing water (urine)
5) Becoming dependant on codeine
6) You get infections or bruise more easily.
7) Difficulty in breathing.